CCL5   Click here for help

GtoPdb Ligand ID: 758

Synonyms: eosinophil chemotactic cytokine [EoCP] | regulated upon activation normal T cell expressed and secreted (RANTES)
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL5 (also known as RANTES- an acronym for regulated on activation, normal T cell expressed and secreted) is a CC family chemokine, that has HIV suppressive activity, as do the related CD8+ T cell chemokines CCL3 and CCL4.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Baba M, Nishimura O, Kanzaki N, Okamoto M, Sawada H, Iizawa Y, Shiraishi M, Aramaki Y, Okonogi K, Ogawa Y et al.. (1999)
A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity.
Proc Natl Acad Sci USA, 96 (10): 5698-703. [PMID:10318947]
2. Combadiere C, Ahuja SK, Van Damme J, Tiffany HL, Gao JL, Murphy PM. (1995)
Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B.
J Biol Chem, 270: 29671-29675. [PMID:8530354]
3. Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS. (1996)
Cloning, expression, and characterization of the human eosinophil eotaxin receptor.
J Exp Med, 183 (5): 2349-54. [PMID:8642344]
4. Hesselgesser J, Ng HP, Liang M, Zheng W, May K, Bauman JG, Monahan S, Islam I, Wei GP, Ghannam A et al.. (1998)
Identification and characterization of small molecule functional antagonists of the CCR1 chemokine receptor.
J Biol Chem, 273 (25): 15687-92. [PMID:9624164]
5. Ignatov A, Robert J, Gregory-Evans C, Schaller HC. (2006)
RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75.
Br J Pharmacol, 149 (5): 490-7. [PMID:17001303]
6. Maghazachi AA, Al-Aoukaty A, Schall TJ. (1996)
CC chemokines induce the generation of killer cells from CD56+ cells.
Eur J Immunol, 26 (2): 315-9. [PMID:8617297]
7. Napier C, Sale H, Mosley M, Rickett G, Dorr P, Mansfield R, Holbrook M. (2005)
Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human.
Biochem Pharmacol, 71 (1-2): 163-72. [PMID:16298345]
8. Ruffing N, Sullivan N, Sharmeen L, Sodroski J, Wu L. (1998)
CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells.
Cell Immunol, 189 (2): 160-8. [PMID:9790730]
9. Song A, Nikolcheva T, Krensky AM. (2000)
Transcriptional regulation of RANTES expression in T lymphocytes.
Immunol Rev, 177: 236-45. [PMID:11138780]
10. Southern C, Cook JM, Neetoo-Isseljee Z, Taylor DL, Kettleborough CA, Merritt A, Bassoni DL, Raab WJ, Quinn E, Wehrman TS et al.. (2013)
Screening β-Arrestin Recruitment for the Identification of Natural Ligands for Orphan G-Protein-Coupled Receptors.
J Biomol Screen, 18 (5): 599-609. [PMID:23396314]
11. Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. (1998)
Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
J Biol Chem, 273 (29): 18288-91. [PMID:9660793]