HX 531

Ligand id: 8079

Name: HX 531

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 96.04
Molecular weight 483.22
XLogP 7.91
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at nuclear hormone receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Retinoid X receptor-α Hs Antagonist Antagonist 6.1 pIC50 - 2
pIC50 6.1 (IC50 9x10-7 M) [2]
Description: Measuring inhibition of agonist-induced activation of RXRα.
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