Ligand id: 8766

Name: JNJ-63533054

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 58.2
Molecular weight 316.1
XLogP 3.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In vivo activity is reported by Shoblock et al. (2019), but these studies failed to clarify the physiological function of GPR139 [4].
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPR139 Hs Agonist Agonist 7.6 pKi - 3
pKi 7.6 (Ki 2.4x10-8 M) [3]