connective tissue growth factor   Click here for help

GtoPdb Ligand ID: 8927

Abbreviated name: CTGF
Comment: CTGF is a multifunctional growth factor secreted by vascular endothelial cells. CTGF is involved in cell migration, proliferation, and differentiation, plays a role chondrogenesis and is involved in the modulation of extracellular matrix deposition and angiogenesis [1-4]. CTGF is expressed at high levels in several types of human malignancies.
CTGF is a clinical molecular target for the identification of therapeutics for the treatment of fibroproliferative diseases.
The signal peptide sequence is MTAASMGPVRVAFVVLLALCSRPAVG (1-26 of the full length amino acid sequence detailed here).
Species: Human
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
pamrevlumab Peptide Primary target of this compound Hs Antibody Binding 10.0 pKd - 5
pKd 10.0 (Kd 1x10-10 M) [5]
pamrevlumab Peptide Rn Antibody Binding 9.5 pKd - 5
pKd 9.5 (Kd 3x10-10 M) [5]