connective tissue growth factor   Click here for help

GtoPdb Ligand ID: 8927

Abbreviated name: CTGF
Comment: CTGF is a multifunctional growth factor secreted by vascular endothelial cells. CTGF is involved in cell migration, proliferation, and differentiation, plays a role chondrogenesis and is involved in the modulation of extracellular matrix deposition and angiogenesis [1-4]. CTGF is expressed at high levels in several types of human malignancies.
CTGF is a clinical molecular target for the identification of therapeutics for the treatment of fibroproliferative diseases.
The signal peptide sequence is MTAASMGPVRVAFVVLLALCSRPAVG (1-26 of the full length amino acid sequence detailed here).
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CCN2 cellular communication network factor 2 Human connective tissue growth factor precursor CCN2, connective tissue growth factor, CTGF, IGFBP8
Database Links Click here for help
Ensembl Gene ENSG00000118523 (Hs)
Entrez Gene 1490 (Hs)
GtoPdb PubChem SID 310264708
Human Protein Atlas ENSG00000118523 (Hs)
OMIM 121009 (Hs)
UniProtKB P29279 (Hs)