connective tissue growth factor   Click here for help

GtoPdb Ligand ID: 8927

Abbreviated name: CTGF
Comment: CTGF is a multifunctional growth factor secreted by vascular endothelial cells. CTGF is involved in cell migration, proliferation, and differentiation, plays a role chondrogenesis and is involved in the modulation of extracellular matrix deposition and angiogenesis [1-4]. CTGF is expressed at high levels in several types of human malignancies.
CTGF is a clinical molecular target for the identification of therapeutics for the treatment of fibroproliferative diseases.
The signal peptide sequence is MTAASMGPVRVAFVVLLALCSRPAVG (1-26 of the full length amino acid sequence detailed here).
Species: Human
1. Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K, Ikeda E, Takata S, Kobayashi K, Okada Y. (2002)
Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis.
FASEB J, 16 (2): 219-21. [PMID:11744618]
2. Kondo S, Kubota S, Shimo T, Nishida T, Yosimichi G, Eguchi T, Sugahara T, Takigawa M. (2002)
Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases.
Carcinogenesis, 23 (5): 769-76. [PMID:12016149]
3. Shimo T, Kubota S, Kondo S, Nakanishi T, Sasaki A, Mese H, Matsumura T, Takigawa M. (2001)
Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line.
Cancer Lett, 174 (1): 57-64. [PMID:11675152]
4. Shimo T, Nakanishi T, Nishida T, Asano M, Sasaki A, Kanyama M, Kuboki T, Matsumura T, Takigawa M. (2001)
Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis.
Oncology, 61 (4): 315-22. [PMID:11721179]
5. Wang Q, Usinger W, Nichols B, Gray J, Xu L, Seeley TW, Brenner M, Guo G, Zhang W, Oliver N et al.. (2011)
Cooperative interaction of CTGF and TGF-β in animal models of fibrotic disease.
Fibrogenesis Tissue Repair, 4 (1): 4. [PMID:21284856]