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Synonyms: CUDC 907 | CUDC-907 | PI3K/HDAC Inhibitor centn
Compound class: Synthetic organic
Comment: Fimepinostat (CUDC-907) is an investigational dual inhibitor of histone deacetylase (HDAC) and phosphatidylinositol 3-kinase (PI3K) activity . The compound is orally available.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|CUDC-907 shows greater growth inhibition and proapoptotic activity than single-target PI3K or HDAC inhibitors in vitro and in xenograft models .
In addition to the interactions in the table below, CUDC-907 also inhibits HDACs 4, 5, 7, 8 and 9 albeit with lower IC50 values (409, 674, 426, 191, 554nM respectively) .
|Selectivity at enzymes|
|Key to terms and symbols||Click column headers to sort|