mucosal addressin cell adhesion molecule 1   Click here for help

GtoPdb Ligand ID: 9339

Abbreviated name: MAdCAM-1
Synonyms: addressin | MAdCAM1
Immunopharmacology Ligand
Comment: MAdCAM-1 is an extracellular immunoglobulin-like peptide expressed on endothelial cells of intestinal lymphoid tissue [5,7], where it plays a role in gut immune surveillance. It is the ligand for homing receptors (e.g. α4β7 and α4β1 integrins, and L-selectin) on lymphocytes and it acts to direct leukocytes into mucosal and inflamed tissues. The α4β7/MAdCAM-1 interaction is gut-specific. MAdCAM-1 is being investigated as a drug target with potential for management of inflammatory bowel conditions [1,3,6,9]. It has also been identified as a mechanistic target that regulates gut dysbiosis during immune checkpoint blockade cancer treatment [2,4].

The peptide details we provide are for the α isoform, which forms from the longest and predominant transcript. Soluble MAdCAM-1 can be detected in serum.
Species: Human
Bioactivity Comments
MAdCAM-1 expression is elevated in intestinal biopsies from experimental models of colitis and from patients with Crohn's disease and ulcerative colitis.
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
ontamalimab Primary target of this compound Hs Antibody Binding 9.7 – 10.8 pKd - 8
pKd 10.8 (Kd 1.61x10-11 M) [8]
Description: Measured in a SPR assay using recombinant human MAdCAM1.
pKd 9.8 (Kd 1.55x10-10 M) [8]
Description: Measured in a back-scattering interferometry (BSI) assay using membrane-bound MAdCAM1.
pKd 9.7 (Kd 2.07x10-10 M) [8]
Description: Measured in a back-scattering interferometry (BSI) assay using soluble MAdCAM1.