mucosal addressin cell adhesion molecule 1

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Ligands
mucosal addressin cell adhesion molecule 1 (Human)

GtoPdb Ligand ID: 9339

Abbreviated name: MAdCAM-1

Synonyms: addressin | MAdCAM1

Compound class: Endogenous peptide in human, mouse or rat

Comment: MAdCAM-1 is an extracellular immunoglobulin-like peptide expressed on endothelial cells of intestinal lymphoid tissue [1-2], where it plays a role in role in gut immune surveillance. It is the ligand for homing receptors (e.g. α4β7 and α4β1 integrins, and L-selectin) on lymphocytes and it acts to direct leukocytes into mucosal and inflamed tissues. The α4β7/MAdCAM-1 interaction is gut-specific. MAdCAM-1 is being investigated as a drug target with potential for management of inflammatory bowel conditions.

The peptide details we provide are for the α isoform, which forms from the longest and predominant transcript. Soluble MAdCAM-1 can be detected in serum.

Species: Human

References
1. Ogawa H, Binion DG, Heidemann J, Theriot M, Fisher PJ, Johnson NA, Otterson MF, Rafiee P. (2005) Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells. Am J Physiol, Cell Physiol, 288 (2): C272-81. [PMID:15483224]
2. Streeter PR, Berg EL, Rouse BT, Bargatze RF, Butcher EC. (1988) A tissue-specific endothelial cell molecule involved in lymphocyte homing. Nature, 331 (6151): 41-6. [PMID:3340147]
3. Wang M, Kussrow AK, Ocana MF, Chabot JR, Lepsy CS, Bornhop DJ, O'Hara DM. (2017) Physiologically relevant binding affinity quantification of monoclonal antibody PF-00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation. Br J Pharmacol, 174 (1): 70-81. [PMID:27760281]

References

1. Ogawa H, Binion DG, Heidemann J, Theriot M, Fisher PJ, Johnson NA, Otterson MF, Rafiee P. (2005)
Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells.
Am J Physiol, Cell Physiol, 288 (2): C272-81. [PMID:15483224]

2. Streeter PR, Berg EL, Rouse BT, Bargatze RF, Butcher EC. (1988)
A tissue-specific endothelial cell molecule involved in lymphocyte homing.
Nature, 331 (6151): 41-6. [PMID:3340147]

3. Wang M, Kussrow AK, Ocana MF, Chabot JR, Lepsy CS, Bornhop DJ, O'Hara DM. (2017)
Physiologically relevant binding affinity quantification of monoclonal antibody PF-00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation.
Br J Pharmacol, 174 (1): 70-81. [PMID:27760281]