mucosal addressin cell adhesion molecule 1   Click here for help

GtoPdb Ligand ID: 9339

Abbreviated name: MAdCAM-1
Synonyms: addressin | MAdCAM1
Immunopharmacology Ligand
Comment: MAdCAM-1 is an extracellular immunoglobulin-like peptide expressed on endothelial cells of intestinal lymphoid tissue [5,7], where it plays a role in gut immune surveillance. It is the ligand for homing receptors (e.g. α4β7 and α4β1 integrins, and L-selectin) on lymphocytes and it acts to direct leukocytes into mucosal and inflamed tissues. The α4β7/MAdCAM-1 interaction is gut-specific. MAdCAM-1 is being investigated as a drug target with potential for management of inflammatory bowel conditions [1,3,6,9]. It has also been identified as a mechanistic target that regulates gut dysbiosis during immune checkpoint blockade cancer treatment [2,4].

The peptide details we provide are for the α isoform, which forms from the longest and predominant transcript. Soluble MAdCAM-1 can be detected in serum.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
addressin | MAdCAM1
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 Human mucosal addressin cell adhesion molecule 1 isoform a precursor -
Database Links Click here for help
Ensembl Gene ENSG00000099866 (Hs)
GtoPdb PubChem SID 328083442
Human Protein Atlas ENSG00000099866 (Hs)
UniProtKB Q13477