PF-00547659

Ligand id: 9340

Name: PF-00547659

Bioactivity Comments
PF-00547659 binding exhbits >30-fold difference in target affinity between in vitro SPR (surface plasmon resonance) derived KD and clinically derived KD, thought to be due to conformational restrictions in membrane-bound MAdCAM-1 compared to soluble MAdCAM-1 [4].
Other ligands which bind to or alter the activity of this ligand
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Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
mucosal addressin cell adhesion molecule 1 {Sp: Human} Hs Antibody Binding 9.7 – 10.8 pKd - 4
pKd 10.8 (Kd 1.61x10-11 M) [4]
Description: Measured in a SPR assay using recombinant human MAdCAM1.
pKd 9.8 (Kd 1.55x10-10 M) [4]
Description: Measured in a back-scattering interferometry (BSI) assay using membrane-bound MAdCAM1.
pKd 9.7 (Kd 2.07x10-10 M) [4]
Description: Measured in a back-scattering interferometry (BSI) assay using soluble MAdCAM1.