Ligand id: 9340

Name: PF-00547659

Immunopharmacology Comments
MAdCAM-1 binding by PF-00547659 selectively reduces lymphocyte homing to the intestinal tract by blocking interaction with integrin α4β7 [1].
Immunopharmacology Disease
Disease X-Refs Comment References
Crohn's disease Disease Ontology: DOID:8778
OMIM: 266600
Orphanet: ORPHA206
Phase 2 clinical candidate for CD (see completed study NCT01298492).
Ulcerative colitis Disease Ontology: DOID:8577
OMIM: 266600
Orphanet: ORPHA771
Phase 2 clinical candidate for UC (see NCT01771809). 3