compound 8c [PMID: 28760529]

Ligand id: 9671

Name: compound 8c [PMID: 28760529]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 102.73
Molecular weight 417.11
XLogP 2.95
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
BCL6 transcription repressor Hs Inhibitor Binding 6.1 – 7.0 pIC50 - 1
pIC50 7.0 (IC50 1x10-7 M) [1]
Description: In a cell-free ELISA system measuring ability to inhibit BCL6 BTB domain-NCoR interaction.
pIC50 6.1 (IC50 7.2x10-7 M) [1]
Description: In a cell-based mammalian two-hybrid system assessing inhibition of protein-protein interaction between BCL6 BTB domain and BCoR.