lofexidine

Ligand id: 9868

Name: lofexidine

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 33.62
Molecular weight 258.03
XLogP 3.14
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
α2A-adrenoceptor Hs Agonist Agonist 8.4 pKi - 1
pKi 8.4 (Ki 4.36x10-9 M) [1]
Description: Calculated from [3H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α2A-AR.
α2B-adrenoceptor Hs Agonist Agonist 7.2 pKi - 1
pKi 7.2 (Ki 6.77x10-8 M) [1]
Description: Calculated from [3H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α2B-AR.
α2C-adrenoceptor Hs Agonist Agonist 7.2 pKi - 1
pKi 7.2 (Ki 6.92x10-8 M) [1]
Description: Calculated from [3H]RS-79948-197 radioligand competition binding to membrane preparations from CHO cells expressing human α2C-AR.