cefteram   Click here for help

GtoPdb Ligand ID: 11051

Synonyms: cefterame | ceftetrame | CFTM | Ro 19-5247 | T-2525
Approved drug
cefteram is an approved drug (Japan)
Compound class: Synthetic organic
Comment: Cefteram is a semisynthetic, third generation cephalosporin (β-lactam) compound with broad-spectrum antibacterial activity. To provide acceptable bioavailability for oral use it is formulated as a pivoxil ester prodrug (cefteram pivoxil, T-2588, PubChem CID 5362114).
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 244.35
Molecular weight 479.08
XLogP -2.39
No. Lipinski's rules broken 1
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Canonical SMILES CO/N=C(\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)Cn1nnc(n1)C)/c1csc(n1)N
Isomeric SMILES CO/N=C(\C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)Cn1nnc(n1)C)/c1csc(n1)N
InChI InChI=1S/C16H17N9O5S2/c1-6-20-23-24(21-6)3-7-4-31-14-10(13(27)25(14)11(7)15(28)29)19-12(26)9(22-30-2)8-5-32-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,26)(H,28,29)/b22-9-/t10-,14-/m1/s1
No information available.
Summary of Clinical Use Click here for help
There is no information regarding approval for clinical use of this drug on the US FDA or European Medicines Agency (EMA) websites. Cefteram pivoxil has been granted marketing authorisation in Japan (sold as Tomiron®) where it is used in the treatment of otitis media, sinusitis, urinary tract infections (including cystitis and pyelonephritis) and respiratory infections(Pharyngitis or laryngitis, tonsillitis (including peritonsilli- tis and peritonsillar abscess), acute bronchitis and pneu- monia, caused by susceptible bacteria.