Ligand id: 1152

Name: VIP

Species: Human, Mouse, Rat

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: vasoactive intestinal peptide

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
No information available.
Summary of Clinical Use
Clinical evaluation of VIP as an inhalation therapeutic for the treatment of pulmonary hypertension in COPD patients (NCT00464932) has been completed, but there is no indication of further development. Clinical use of native VIP is limited by its short circulating half-life and its gastrointestinal side-effects caused by activation of VPAC1 receptors which are found predominantly in the gastrointestinal tract. To overcome these limitations PHASEBio have developed a congugated VIP analogue that has an extended half-life (~60 hours) and selectivity for myocardial VPAC2 receptors. Coded as PB1046 (VasomeraTM), this synthetic VIP has advanced to Phase 2 clinical trial for evaluation as a once-weekly injection for patients with pulmonary arterial hypertension (see NCT03556020).
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT00464932 Vasoactive Intestinal Peptide in COPD Observational Medical University of Vienna
NCT03556020 Phase 2 Study to Assess Safety, Tolerability and Efficacy of Once Weekly SC PB1046 in Subjects With Symptomatic PAH Phase 2 Interventional PhaseBio Pharmaceuticals Inc.