VIP

Ligand id: 1152

Name: VIP

Species: Human, Mouse, Rat

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Structure and Physico-chemical Properties

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Summary of Clinical Use
Clinical evaluation of VIP as an inhalation therapeutic for the treatment of pulmonary hypertension in COPD patients (NCT00464932) has been completed, but there is no indication of further development. Clinical use of native VIP is limited by its short circulating half-life and its gastrointestinal side-effects caused by activation of VPAC1 receptors which are found predominantly in the gastrointestinal tract. To overcome these limitations PHASEBio have developed a congugated VIP analogue that has an extended half-life (~60 hours) and selectivity for myocardial VPAC2 receptors. Coded as PB1046 (VasomeraTM), this synthetic VIP has advanced to Phase 2 clinical trial for evaluation as a once-weekly injection for patients with pulmonary arterial hypertension (see NCT03556020).