Ligand id: 1152

Name: VIP

Species: Human, Mouse, Rat

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View more information in the IUPHAR Pharmacology Education Project: vasoactive intestinal peptide

Structure and Physico-chemical Properties

2D Structure
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1. Benitez R, Delgado-Maroto V, Caro M, Forte-Lago I, Duran-Prado M, O'Valle F, Lichtman AH, Gonzalez-Rey E, Delgado M. (2018)
Vasoactive Intestinal Peptide Ameliorates Acute Myocarditis and Atherosclerosis by Regulating Inflammatory and Autoimmune Responses.
J. Immunol., 200 (11): 3697-3710. [PMID:29669783]
2. Ciccarelli E, Svoboda M, De Neef P, Di Paolo E, Bollen A, Dubeaux C, Vilardaga JP, Waelbroeck M, Robberecht P. (1995)
Pharmacological properties of two recombinant splice variants of the PACAP type I receptor, transfected and stably expressed in CHO cells.
Eur. J. Pharmacol., 288 (3): 259-67. [PMID:7774670]
3. Dautzenberg FM, Mevenkamp G, Wille S, Hauger RL. (1999)
N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants.
J. Neuroendocrinol., 11 (12): 941-9. [PMID:10583729]
4. Dickson L, Aramori I, McCulloch J, Sharkey J, Finlayson K. (2006)
A systematic comparison of intracellular cyclic AMP and calcium signalling highlights complexities in human VPAC/PAC receptor pharmacology.
Neuropharmacology, 51 (6): 1086-98. [PMID:16930633]
5. Gaudin P, Couvineau A, Maoret JJ, Rouyer-Fessard C, Laburthe M. (1996)
Stable expression of the recombinant human VIP1 receptor in clonal Chinese hamster ovary cells: pharmacological, functional and molecular properties.
Eur. J. Pharmacol., 302 (1-3): 207-14. [PMID:8791009]
6. Gourlet P, Rathé J, De Neef P, Cnudde J, Vandermeers-Piret MC, Waelbroeck M, Robberecht P. (1998)
Interaction of lipophilic VIP derivatives with recombinant VIP1/PACAP and VIP2/PACAP receptors.
Eur. J. Pharmacol., 354 (1): 105-11. [PMID:9726637]
7. Gourlet P, Vandermeers A, Van Rampelbergh J, De Neef P, Cnudde J, Waelbroeck M, Robberecht P. (1998)
Analogues of VIP, helodermin, and PACAP discriminate between rat and human VIP1 and VIP2 receptors.
Ann. N. Y. Acad. Sci., 865: 247-52. [PMID:9928018]
8. Gourlet P, Vandermeers A, Vertongen P, Rathe J, De Neef P, Cnudde J, Waelbroeck M, Robberecht P. (1997)
Development of high affinity selective VIP1 receptor agonists.
Peptides, 18 (10): 1539-45. [PMID:9437714]
9. Ishihara T, Nakamura S, Kaziro Y, Takahashi T, Takahashi K, Nagata S. (1991)
Molecular cloning and expression of a cDNA encoding the secretin receptor.
EMBO J., 10 (7): 1635-41. [PMID:1646711]
10. Juarranz MG, Van Rampelbergh J, Gourlet P, De Neef P, Cnudde J, Robberecht P, Waelbroeck M. (1999)
Different vasoactive intestinal polypeptide receptor domains are involved in the selective recognition of two VPAC(2)-selective ligands.
Mol. Pharmacol., 56 (6): 1280-7. [PMID:10570056]
11. Moody TW, Jensen RT, Fridkin M, Gozes I. (2002)
(N-stearyl, norleucine17)VIPhybrid is a broad spectrum vasoactive intestinal peptide receptor antagonist.
J. Mol. Neurosci., 18 (1-2): 29-35. [PMID:11931347]
12. Mutt V, Said SI. (1974)
Structure of the porcine vasoactive intestinal octacosapeptide. The amino-acid sequence. Use of kallikrein in its determination.
Eur. J. Biochem., 42 (2): 581-9. [PMID:4829446]
13. Nicole P, Du K, Couvineau A, Laburthe M. (1998)
Site-directed mutagenesis of human vasoactive intestinal peptide receptor subtypes VIP1 and VIP2: evidence for difference in the structure-function relationship.
J. Pharmacol. Exp. Ther., 284 (2): 744-50. [PMID:9454823]
14. Nicole P, Lins L, Rouyer-Fessard C, Drouot C, Fulcrand P, Thomas A, Couvineau A, Martinez J, Brasseur R, Laburthe M. (2000)
Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide.
J. Biol. Chem., 275 (31): 24003-12. [PMID:10801840]
15. Said SI, Mutt V. (1972)
Isolation from porcine-intestinal wall of a vasoactive octacosapeptide related to secretin and to glucagon.
Eur. J. Biochem., 28 (2): 199-204. [PMID:5069712]
16. Sreedharan SP, Patel DR, Huang JX, Goetzl EJ. (1993)
Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor.
Biochem Biophys Res Commun, 193: 546-553. [PMID:8390245]
17. Sreedharan SP, Patel DR, Xia M, Ichikawa S, Goetzl EJ. (1994)
Human vasoactive intestinal peptide1 receptors expressed by stable transfectants couple to two distinct signaling pathways.
Biochem. Biophys. Res. Commun., 203 (1): 141-8. [PMID:8074647]
18. Xia M, Sreedharan SP, Bolin DR, Gaufo GO, Goetzl EJ. (1997)
Novel cyclic peptide agonist of high potency and selectivity for the type II vasoactive intestinal peptide receptor.
J. Pharmacol. Exp. Ther., 281 (2): 629-33. [PMID:9152366]