Ligand id: 1152

Name: VIP

Species: Human, Mouse, Rat

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View more information in the IUPHAR Pharmacology Education Project: vasoactive intestinal peptide

Structure and Physico-chemical Properties

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Immunopharmacology Comments
In addition to its vascular and cardioprotective functions, VIP also regulates immune function and inflammatory responses. In a mouse model of autoimmune myocarditis, admninistration of VIP reduced signs of heart damage and reduced myocardial inflammatory infiltration and levels of myocardial autoantibodies [1]. In an atherosclerosis model, the anti-inflammatory effects of VIP included a reduction in Th1-driven inflammatory responses and an elevation in regulatory T cell numbers in atherosclerotic arteries and their draining lymph nodes. Together these findings suggest that VIP may be a valid therapeutic option for the treatment of heart inflammation and atherosclerosis.