Ligand id: 1627

Name: morphine

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View more information in the IUPHAR Pharmacology Education Project: morphine

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 52.93
Molecular weight 285.14
XLogP 0.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment and management of severe pain.
Mechanism Of Action and Pharmacodynamic Effects
Morphine appears to mimic the actions of the endogenous opioids, endorphins, enkephalins and dynorphins. Morphine interacts predominantly with the μ-δ-opioid (Mu-Delta) receptor heteromer in the central nervous system to produce therapeutic effects of analgesia and sedation. Activation of μ receptors in the gut causes opioid-induced constipation.
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