morphine   Click here for help

GtoPdb Ligand ID: 1627

Synonyms: morphine sulfate | Ms Contin® | Oramorph®
Approved drug PDB Ligand
morphine is an approved drug (FDA (1984), prior history not available)
Comment: Morphine is an opiate class compound, isolated from the opium poppy (Papaver somniferum). It is a fast-acting narcotic. Morphine is used to make other opioids such as hydromorphone, oxycodone and diamorphine (heroin).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 52.93
Molecular weight 285.14
XLogP 0.49
No. Lipinski's rules broken 0
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Canonical SMILES OC1C=CC2C34C1Oc1c4c(CC2N(CC3)C)ccc1O
Isomeric SMILES O[C@H]1C=C[C@@H]2[C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)C)ccc1O
InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
μ receptor Primary target of this compound Hs Agonist Full agonist 9.0 pKi - 2,5
pKi 9.0 [2,5]
μ receptor Rn Agonist Partial agonist 7.9 pKi - 4
pKi 7.9 [4]
κ receptor Hs Agonist Partial agonist 7.3 pKi - 5
pKi 7.3 [5]
δ receptor Hs Agonist Full agonist 6.9 pKi - 5
pKi 6.9 [5]
κ receptor Rn Agonist Partial agonist 6.7 – 7.0 pKi - 1,3
pKi 6.7 – 7.0 [1,3]
Ligand mentioned in the following text fields