trazodone   Click here for help

GtoPdb Ligand ID: 213

Synonyms: AF-1161 | Desyrel® | Molipaxin® | Oleptro®
Approved drug
trazodone is an approved drug (FDA (1981))
Compound class: Synthetic organic
Comment: Marketed formulations may contain trazodone hydrochloride (PubChem CID 62935).
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View more information in the IUPHAR Pharmacology Education Project: trazodone

2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 45.78
Molecular weight 371.15
XLogP 3.94
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2
Isomeric SMILES Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2
InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2
InChI Key PHLBKPHSAVXXEF-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Used in the treatment of major depressive disorder.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Primarily acts as an antagonist of the serotonin 5-HT2A and 5-HT2C receptors. May have some inhibitory effect on serotonin reuptake via the serotonin transporter (SERT, SLC6A4).
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