trazodone   Click here for help

GtoPdb Ligand ID: 213

Synonyms: AF-1161 | Desyrel® | Molipaxin® | Oleptro®
Approved drug
trazodone is an approved drug (FDA (1981))
Compound class: Synthetic organic
Comment: Marketed formulations may contain trazodone hydrochloride (PubChem CID 62935).
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: trazodone

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 45.78
Molecular weight 371.15
XLogP 3.94
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2
Isomeric SMILES Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2
InChI InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2
No information available.
Summary of Clinical Use Click here for help
Used in the treatment of major depressive disorder.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Primarily acts as an antagonist of the serotonin 5-HT2A and 5-HT2C receptors. May have some inhibitory effect on serotonin reuptake via the serotonin transporter (SERT, SLC6A4).
External links Click here for help