(-)-menthol   Click here for help

GtoPdb Ligand ID: 2430

Synonyms: l-menthol | levomenthol
Approved drug
(-)-menthol is an approved drug (FDA (2008), no prior history available)
Comment: Natural menthol principally occurs as the (-)-enantiomer, also known as levomenthol. This (-)-enantiomer is also one of the components of the INN-assigned racementhol.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 20.23
Molecular weight 156.15
XLogP 3.21
No. Lipinski's rules broken 0
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Canonical SMILES CC1CCC(C(C1)O)C(C)C
Isomeric SMILES C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C
InChI InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1
No information available.
Summary of Clinical Use Click here for help
Menthol is used to treat minor irritation of the mouth or throat and cough symptoms associated with colds.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Activator of cold-sensitive TRPM8 receptors found in the skin.