Synonyms: l-menthol | levomenthol
(-)-menthol is an approved drug (FDA (2008), no prior history available)
Compound class:
Natural product
Comment: Natural menthol principally occurs as the (-)-enantiomer, also known as levomenthol. This (-)-enantiomer is also one of the components of the INN-assigned racementhol.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Andersson DA, Chase HW, Bevan S. (2004)
TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH. J Neurosci, 24 (23): 5364-9. [PMID:15190109] |
2. Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R. (2004)
Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol, 141 (4): 737-45. [PMID:14757700] |
3. Karashima Y, Damann N, Prenen J, Talavera K, Segal A, Voets T, Nilius B. (2007)
Bimodal action of menthol on the transient receptor potential channel TRPA1. J Neurosci, 27 (37): 9874-84. [PMID:17855602] |
4. Macpherson LJ, Hwang SW, Miyamoto T, Dubin AE, Patapoutian A, Story GM. (2006)
More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci, 32 (4): 335-43. [PMID:16829128] |
5. McKemy DD, Neuhausser WM, Julius D. (2002)
Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature, 416 (6876): 52-8. [PMID:11882888] |
6. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B. (2004)
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature, 430 (7001): 748-54. [PMID:15306801] |
7. Xiao B, Dubin AE, Bursulaya B, Viswanath V, Jegla TJ, Patapoutian A. (2008)
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci, 28 (39): 9640-51. [PMID:18815250] |