isoflurane   Click here for help

GtoPdb Ligand ID: 2505

Synonyms: Forane®
Approved drug
isoflurane is an approved drug (FDA (1979))
Comment: Isoflurane is an inhalation anaesthetic.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 9.23
Molecular weight 183.97
XLogP 2.6
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES FC(OC(C(F)(F)F)Cl)F
Isomeric SMILES FC(OC(C(F)(F)F)Cl)F
InChI InChI=1S/C3H2ClF5O/c4-1(3(7,8)9)10-2(5)6/h1-2H
InChI Key PIWKPBJCKXDKJR-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Isoflurane is an inhalation anesthetic, used in the induction and maintenance of general anaesthesia.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Isoflurane reduces tissue excitability by decreasing the extent of gap junction mediated cell-cell coupling. The mechanism appears to involve modulating the activity of the channels that underlie the action potential (including GABAA receptors, potassium channels of the KCNK family, and the glutamate and glycine receptors). Due to the complex nature of this drug's MMOA, and the paucity of (human) affinity data, we do not tag a primary drug target.