Ligand id: 2505

Name: isoflurane

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 9.23
Molecular weight 183.97
XLogP 2.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
K2P16.1 Hs Activator - - - 7x10-4 - 9x10-4 1
Conc range: 7x10-4 - 9x10-4 M [1]
TRPA1 Rn Activator Activation 3.7 pEC50 - 2
pEC50 3.7 [2]
Description: Patch clamp
Conditions: HEK293 cells expressing rat TRPA1
K2P3.1 Rn Activator Positive 2.7 pEC50 - 4
pEC50 2.7 [4]
K2P2.1 Hs Activator - - - - 3
studied at 1-5 mM [3]
Ligand mentioned in the following text fields