camicinal   Click here for help

GtoPdb Ligand ID: 4035

Synonyms: GSK 962040 | GSK962040
Compound class: Synthetic organic
Comment: Camicinal is a motilin receptor agonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 47.61
Molecular weight 424.26
XLogP 3.16
No. Lipinski's rules broken 0
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Canonical SMILES CC1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F
Isomeric SMILES C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F
InChI InChI=1S/C25H33FN4O/c1-19-17-29(14-11-27-19)18-21-7-5-20(6-8-21)15-25(31)30-12-9-23(10-13-30)28-24-4-2-3-22(26)16-24/h2-8,16,19,23,27-28H,9-15,17-18H2,1H3/t19-/m0/s1
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Summary of Clinical Use Click here for help
Camicinal was assessed in clinical trials as a treatment for delayed gastric emptying (gastroparesis). Click here to link to's full list of camicinal trials. It did not appear to progress beyond Phase 2 despite evidence that it accelerated gastric emptying and increased glucose absorption in target patients [2].
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Gastroparesis can occur when the vagus nerve (which controls stomach contractions) or muscles of the stomach and intestines fail to function normally. This slows or stops gastro-intestinal transit in the digestive tract. Gastroparesis can be the result of autonomic neuropathy which is associated with diabetes, Parkinson's disease and other diseases, or as a result of abdominal surgery. Camicinal-induced activation of the motilin receptor stimulates contraction of gut smoooth muscle, to improve gut motility [1,3].