camicinal   Click here for help

GtoPdb Ligand ID: 4035

Synonyms: GSK 962040 | GSK962040
Compound class: Synthetic organic
Comment: Camicinal is a motilin receptor agonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 47.61
Molecular weight 424.26
XLogP 3.16
No. Lipinski's rules broken 0
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Canonical SMILES CC1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F
Isomeric SMILES C[C@@H]1NCCN(C1)Cc1ccc(cc1)CC(=O)N1CCC(CC1)Nc1cccc(c1)F
InChI InChI=1S/C25H33FN4O/c1-19-17-29(14-11-27-19)18-21-7-5-20(6-8-21)15-25(31)30-12-9-23(10-13-30)28-24-4-2-3-22(26)16-24/h2-8,16,19,23,27-28H,9-15,17-18H2,1H3/t19-/m0/s1
1. Barshop K, Kuo B. (2015)
The investigational drug camicinal for the treatment of gastroparesis.
Expert Opin Investig Drugs, 24 (1): 133-140. [PMID:25341626]
2. Chapman MJ, Deane AM, O'Connor SL, Nguyen NQ, Fraser RJ, Richards DB, Hacquoil KE, Vasist Johnson LS, Barton ME, Dukes GE. (2016)
The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-controlled, clinical trial.
Crit Care, 20 (1): 232. [PMID:27476581]
3. Peeters TL. (2015)
Gastrointestinal hormones and gut motility.
Curr Opin Endocrinol Diabetes Obes, 22 (1): 9-13. [PMID:25517024]
4. Sanger GJ, Westaway SM, Barnes AA, Macpherson DT, Muir AI, Jarvie EM, Bolton VN, Cellek S, Näslund E, Hellström PM et al.. (2009)
GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility.
Neurogastroenterol Motil, 21 (6): 657-64, e30-1. [PMID:19374732]