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Synonyms: ADS-5102 | Gocovri® | Symadine® | Symmetrel®
amantadine is an approved drug (FDA (1966))
Compound class: Synthetic organic
Comment: Chemically amantadine has an adamantane backbone with an amino group substituted at one of the four methyne positions. Clinically it has antiviral (blocking the viral M2 proton channel) and antiparkinsonian actions.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|Amantadine has historically been used as an antiviral agent to treat influenza, but as the flu virus has become resistant to amantadine this use is no longer recommended.
In August 2017, the US FDA approved Gocovri®, an extended release, high dose formulation of amantadine for the treatment of dyskinesia in Parkinson's disease (PD), for patients already receiving levodopa-based therapy, irrespective of whether or not they are receiving concomitant dopaminergic medications. Clinical trial results showed that Gocovri® reduced both dyskinesia and 'off' time' in levodopa treated PD patients . This first PD approval was followed in February 2018 with FDA approval of Osmolex ER (another extended release formulation of amantadine) for the treatment of PD and for the treatment of drug-induced extrapyramidal reactions. In Europe amantadine is not approved at the EMA level, but is/has been approved in a number of national jurisdictions including the UK, France, Italy, Greece and the Netherlands.
|Mechanism Of Action and Pharmacodynamic Effects|
|Amantadine's MMOA in the treatment of Parkinson's symptoms arises from its multifunctional activity. These actions include, antagonism of the NMDA type glutamate receptor, stimulation of increased dopamine release, and inhibition of dopamine reuptake.|