triamterene   Click here for help

GtoPdb Ligand ID: 4329

Synonyms: Dyrenium® | Dytac® | SK-8542
Approved drug PDB Ligand
triamterene is an approved drug (FDA (1964))
Compound class: Synthetic organic
Comment: Triamterene is a potassium-sparing diuretic.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 129.62
Molecular weight 253.11
XLogP 0.64
No. Lipinski's rules broken 0
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Canonical SMILES Nc1nc(N)c2c(n1)nc(c(n2)c1ccccc1)N
Isomeric SMILES Nc1nc(N)c2c(n1)nc(c(n2)c1ccccc1)N
InChI InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
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Summary of Clinical Use Click here for help
Anti-diuretic used in the treatment of edema associated with congestive heart failure, hepatic cirrhosis, and nephrotic syndrome, and also in the treatment of other forms of edema including idiopathic and steroid-induced.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Inhibits epithelial sodium channels (ENaCs) on principal cells in the late distal convoluted tubule and collecting tubule, inhibiting sodium reabsorption and increasing water loss. This action promotes potassium excretion through apical potassium channels, thereby inhibiting potassium excretion.
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