Synonyms: Dyrenium® | Dytac® | SK-8542
triamterene is an approved drug (FDA (1964))
Compound class:
Synthetic organic
Comment: Triamterene is a potassium-sparing diuretic.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: triamterene |
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References |
1. Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD, Rossier BC. (1994)
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature, 367 (6462): 463-7. [PMID:8107805] |
2. Kellenberger S, Gautschi I, Schild L. (2003)
Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rate. Mol Pharmacol, 64 (4): 848-56. [PMID:14500741] |