Ligand id: 4329

Name: triamterene

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 129.62
Molecular weight 253.11
XLogP 0.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD, Rossier BC. (1994)
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits.
Nature, 367 (6462): 463-7. [PMID:8107805]
2. Kellenberger S, Gautschi I, Schild L. (2003)
Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rate.
Mol. Pharmacol., 64 (4): 848-56. [PMID:14500741]