triamterene   Click here for help

GtoPdb Ligand ID: 4329

Synonyms: Dyrenium® | Dytac® | SK-8542
Approved drug PDB Ligand
triamterene is an approved drug (FDA (1964))
Compound class: Synthetic organic
Comment: Triamterene is a potassium-sparing diuretic.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 129.62
Molecular weight 253.11
XLogP 0.64
No. Lipinski's rules broken 0
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Canonical SMILES Nc1nc(N)c2c(n1)nc(c(n2)c1ccccc1)N
Isomeric SMILES Nc1nc(N)c2c(n1)nc(c(n2)c1ccccc1)N
InChI InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
1. Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD, Rossier BC. (1994)
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits.
Nature, 367 (6462): 463-7. [PMID:8107805]
2. Kellenberger S, Gautschi I, Schild L. (2003)
Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rate.
Mol Pharmacol, 64 (4): 848-56. [PMID:14500741]