eflornithine

Ligand id: 5176

Name: eflornithine

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 89.34
Molecular weight 182.09
XLogP -2.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This drug is used topically to treat facial hirsutism (excessive hair growth) and by injection for African sleeping sickness (trypanosomiasis). The EMA granted eflornithine orphan designation in 2016 for the treament of glioma [2].
Mechanism Of Action and Pharmacodynamic Effects
Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme that catalyses the conversion of ornithine to putrescine, and plays an important role in cell division and proliferation in the hair follicle. In sleeping sickness it is believed eflornithine kills trypanosomes by inhibiting their ornithine decarboxylase enzyme, which in these organisms is required for cell division [4].
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