foretinib

Ligand id: 5679

Name: foretinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 14
Topological polar surface area 111.25
Molecular weight 632.24
XLogP 4.55
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Foretinib was evaluated in several Phase 2 clinical trials as a treatment for many cancer types, including recurrent or metastatic squamous cell cancer of the head and neck, metastatic gastric cancer, renal cell carcinoma (RCC), metastatic breast cancer and advanced or metastatic non-small cell lung cancer (NSCLC). Development was terminated at Phase 2.
Mechanism Of Action and Pharmacodynamic Effects
Foretinib acts to reduce tumour growth through inhibition of proliferation of tumour cells and inhibition of invasion and angiogenesis [4].