foretinib

Ligand id: 5679

Name: foretinib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 14
Topological polar surface area 111.25
Molecular weight 632.24
XLogP 4.55
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Secondary targets include Tie-2, VEGFR3 (FLT4), RON, FLT3 and PDGFRα/β [4].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
MET proto-oncogene, receptor tyrosine kinase Hs Inhibitor Inhibition 8.9 pKd - 1
pKd 8.9 (Kd 1.4x10-9 M) [1]
MET proto-oncogene, receptor tyrosine kinase Hs Inhibitor Inhibition 9.3 – 9.4 pIC50 - 2-3
pIC50 9.3 – 9.4 (IC50 5x10-10 – 4x10-10 M) [2-3]
fms related tyrosine kinase 1 Hs Inhibitor Inhibition 9.1 pIC50 - 3
pIC50 9.1 (IC50 8x10-10 M) [3]
kinase insert domain receptor Hs Inhibitor Inhibition 8.2 – 9.1 pIC50 - 3
pIC50 8.2 – 9.1 (IC50 6.8x10-9 – 8x10-10 M) [3]
fms related tyrosine kinase 4 Hs Inhibitor Inhibition 8.6 pIC50 - 3
pIC50 8.6 (IC50 2.8x10-9 M) [3]