Ligand id: 5680

Name: alvocidib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.14
Molecular weight 401.1
XLogP 3.95
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Alvocidib has progressed to Phase 2 clinical evaluation for anti-cancer potential. Click here to link to's full list of alvocidib trials.
Mechanism Of Action and Pharmacodynamic Effects
Alvocidib is a CDK kinase inhibitor [1,7] which causes cell-cycle arrest and subsequent apoptosis of cancer cells [2,4].