Synonyms: flavopiridol | HL 275 | HMR 1275 | L 86-8275 | L 868275 | MDL-107826A | NSC-649890
Compound class:
Synthetic organic
Comment: Alvocidib is a selective inhibitor of cyclin-dependent kinase (CDK) 2 and CDK4 [2].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
References |
1. Bose P, Simmons GL, Grant S. (2013)
Cyclin-dependent kinase inhibitor therapy for hematologic malignancies. Expert Opin Investig Drugs, 22 (6): 723-38. [PMID:23647051] |
2. Carlson BA, Dubay MM, Sausville EA, Brizuela L, Worland PJ. (1996)
Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells. Cancer Res, 56 (13): 2973-8. [PMID:8674031] |
3. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011)
Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378] |
4. Kaur G, Stetler-Stevenson M, Sebers S, Worland P, Sedlacek H, Myers C, Czech J, Naik R, Sausville E. (1992)
Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. J Natl Cancer Inst, 84 (22): 1736-40. [PMID:1279187] |
5. Losiewicz MD, Carlson BA, Kaur G, Sausville EA, Worland PJ. (1994)
Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275. Biochem Biophys Res Commun, 201 (2): 589-95. [PMID:8002990] |
6. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010)
Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574] |
7. Worland PJ, Kaur G, Stetler-Stevenson M, Sebers S, Sartor O, Sausville EA. (1993)
Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity. Biochem Pharmacol, 46 (10): 1831-40. [PMID:8250970] |