Ligand id: 5680

Name: alvocidib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 94.14
Molecular weight 401.1
XLogP 3.95
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
cyclin dependent kinase 4 Hs Inhibitor Inhibition 7.2 pKi - 2
pKi 7.2 (Ki 6.5x10-8 M) [2]
cyclin dependent kinase 2 Hs Inhibitor Inhibition 6.4 – 7.0 pIC50 - 2,5
pIC50 6.4 – 7.0 (IC50 4x10-7 – 1x10-7 M) [2,5]