levobunolol   Click here for help

GtoPdb Ligand ID: 570

Synonyms: (-)-bunolol | Ak-beta® | BRN 1887243 | L-bunolol | Liquifilm® | W-6421A
Approved drug
levobunolol is an approved drug (FDA (1985))
Compound class: Synthetic organic
Comment: Levobunolol is a nonselective β-adrenoceptor antagonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 58.56
Molecular weight 291.18
XLogP 2.09
No. Lipinski's rules broken 0
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Canonical SMILES OC(COc1cccc2c1CCCC2=O)CNC(C)(C)C
Isomeric SMILES O[C@H](COc1cccc2c1CCCC2=O)CNC(C)(C)C
InChI InChI=1S/C17H25NO3/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3/t12-/m0/s1
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Summary of Clinical Use Click here for help
Levobunolol is used to treat glaucoma or other conditions of elevated intraocular pressure.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Levobunolol's mechanism of action is not clearly defined, but is believed to be due to a reduction of the production of aqueous humor via a catecholamine-dependent mechanism.