levobunolol

Ligand id: 570

Name: levobunolol

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 58.56
Molecular weight 291.18
XLogP 2.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
β2-adrenoceptor Hs Antagonist Antagonist 9.3 pKi - 1
pKi 9.3 (Ki 5.5x10-10 M) [1]
β1-adrenoceptor Hs Antagonist Antagonist 8.4 pKi - 1
pKi 8.4 (Ki 3.99x10-9 M) [1]
β3-adrenoceptor Hs Antagonist Antagonist 6.8 pKi - 2
pKi 6.8 (Ki 1.6x10-7 M) [2]
β3-adrenoceptor Rn Antagonist Antagonist 6.4 pKi - 2
pKi 6.4 [2]
β3-adrenoceptor Mm Antagonist Antagonist 6.2 – 6.3 pKi - 2
pKi 6.2 – 6.3 [2]