Ligand id: 59

Name: ziprasidone

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View more information in the IUPHAR Pharmacology Education Project: ziprasidone

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 76.71
Molecular weight 412.11
XLogP 3.89
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of schizophrenia and related psychotic disorders. Additionally used as a monotherapy for the acute treatment of bipolar manic or mixed episodes and as an adjunct to lithium or valproate for maintenance treatment of bipolar disorder.
Mechanism Of Action and Pharmacodynamic Effects
The antipsychotic effects of ziprasidone are believed to be due to its antagonism of D2 receptors in the mesolimbic pathways and 5HT2A receptors in the frontal cortex.
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