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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
D1 receptor
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D2 receptor
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D3 receptor
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D4 receptor
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D5 receptor
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* Key recommended reading is highlighted with an asterisk
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Subcommittee members:
Raul R. Gainetdinov (Chairperson)
Jean-Martin Beaulieu
Emiliana Borrelli
Marc G. Caron
Gilberto Fisone
David K. Grandy
Maria Cristina Missale
Kim A. Neve (Past chairperson)
David R. Sibley
Pierre Sokoloff
Arvid Carlsson (Past contributor)
Olivier Civelli (Past contributor)
John W. Kebabian (Past contributor)
Saloman Z. Langer (Past contributor)
Bernard Scatton (Past contributor)
Jean-Charles Schwartz (Past chairperson)
Goran Sedvall (Past contributor)
Philip Seeman (Past contributor)
Pierre F. Spano (Past contributor)
Hubert H. M. Van Tol (Past contributor) |
Other contributors:
Stefano Espinoza |
Database page citation (select format):
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: G protein-coupled receptors. Br J Pharmacol. 176 Issue S1: S21-S141.
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The selectivity of many of these agents is less than two orders of magnitude. [3H]Raclopride exhibits similar high affinity for D2 and D3 receptors (low affinity for D4), but has been used to label D2 receptors in the presence of a D3-selective antagonist. [3H]7-OH-DPAT has similar affinity for D2 and D3 receptors, but labels only D3 receptors in the absence of divalent cations. The pharmacological profile of the D5 receptor is similar to, yet distinct from, that of the D1 receptor. The splice variants of the D2 receptor are commonly termed D2S and D2L (short and long). The DRD4 gene encoding the D4 receptor is highly polymorphic in humans, with allelic variations of the protein from amino acid 387 to 515.