brinzolamide   Click here for help

GtoPdb Ligand ID: 6797

Synonyms: AL-4862 | Azopt®
Approved drug PDB Ligand
brinzolamide is an approved drug (FDA (1998), EMA (2000))
Compound class: Synthetic organic
Comment: Carbonic anhydrase inhibitor
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 163.8
Molecular weight 383.06
XLogP -1.6
No. Lipinski's rules broken 0
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Canonical SMILES COCCCN1CC(NCC)c2c(S1(=O)=O)sc(c2)S(=O)(=O)N
Isomeric SMILES COCCCN1C[C@H](NCC)c2c(S1(=O)=O)sc(c2)S(=O)(=O)N
InChI InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
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Summary of Clinical Use Click here for help
Used in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
A highly specific, non-competitive, reversible carbonic anhydrase inhibitor