brinzolamide   Click here for help

GtoPdb Ligand ID: 6797

Synonyms: AL-4862 | Azopt®
Approved drug PDB Ligand
brinzolamide is an approved drug (FDA (1998), EMA (2000))
Compound class: Synthetic organic
Comment: Carbonic anhydrase inhibitor
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 163.8
Molecular weight 383.06
XLogP -1.6
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES COCCCN1CC(NCC)c2c(S1(=O)=O)sc(c2)S(=O)(=O)N
Isomeric SMILES COCCCN1C[C@H](NCC)c2c(S1(=O)=O)sc(c2)S(=O)(=O)N
InChI InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1
InChI Key HCRKCZRJWPKOAR-JTQLQIEISA-N
References
1. Parr JS, Khalifah RG. (1992)
Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters.
J Biol Chem, 267 (35): 25044-50. [PMID:1460006]
2. Sethi KK, Vullo D, Verma SM, Tanç M, Carta F, Supuran CT. (2013)
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.
Bioorg Med Chem, 21 (19): 5973-82. [PMID:23965175]
3. Vullo D, Innocenti A, Nishimori I, Pastorek J, Scozzafava A, Pastoreková S, Supuran CT. (2005)
Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?.
Bioorg Med Chem Lett, 15 (4): 963-9. [PMID:15686894]