GtoPdb Ligand ID: 685

Abbreviated name: CT
Synonyms: LS-173874 | thyrocalcitonin
calcitonin is an approved drug (FDA (1986))
Comment: For an image and identifiers representing the chemical structure of human calcitonin, please see the PubChem entry linked to from this ligand page. The gene encoding human calcitonin also encodes two other isoforms: katacalcin and α-CGRP.
Species: Human
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Mechanism Of Action and Pharmacodynamic Effects
Calcitonin binds to the calcitonin receptor (found primarily in osteoclasts) and enhances the production of vitamin D producing enzymes. This results in increased calcium retention and enhanced osteogenesis and bone density. Binding of calcitonin to its receptor also activates the adenylyl cyclase and phosphatidyl-inositol-calcium signalling pathways.