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Abbreviated name: CT
Synonyms: LS-173874 | thyrocalcitonin
calcitonin is an approved drug (FDA (1986))
Compound class: Endogenous peptide in human, mouse or rat
Comment: For an image and identifiers representing the chemical structure of human calcitonin, please see the PubChem entry linked to from this ligand page. The gene encoding human calcitonin also encodes two other isoforms: katacalcin and α-CGRP.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: calcitonin
1. Albrandt K, Brady EM, Moore CX, Mull E, Sierzega ME, Beaumont K. (1995)
Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene.
Endocrinology, 136 (12): 5377-84. [PMID:7588285]
2. Armour SL, Foord S, Kenakin T, Chen WJ. (1999)
Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor.
J Pharmacol Toxicol Methods, 42 (4): 217-24. [PMID:11033437]
3. Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM. (2005)
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.
Mol. Pharmacol., 67 (5): 1655-65. [PMID:15692146]
4. Kuwasako K, Kitamura K, Nagoshi Y, Eto T. (2003)
Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins.
Biochem. Biophys. Res. Commun., 301 (2): 460-4. [PMID:12565884]
5. Leuthauser K, Gujer R, Aldecoa A, McKinney RA, Muff R, Fischer JA, Born W. (2000)
Receptor-activity-modifying protein 1 forms heterodimers with two G-protein-coupled receptors to define ligand recognition.
Biochem J., 351: 347-351. [PMID:11023820]
6. Muff R, Bühlmann N, Fischer JA, Born W. (1999)
An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3.
Endocrinology, 140 (6): 2924-7. [PMID:10342886]