GtoPdb Ligand ID: 685

Abbreviated name: CT
Synonyms: LS-173874 | thyrocalcitonin
calcitonin is an approved drug (FDA (1986))
Comment: For an image and identifiers representing the chemical structure of human calcitonin, please see the PubChem entry linked to from this ligand page. The gene encoding human calcitonin also encodes two other isoforms: katacalcin and α-CGRP.
Species: Human
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View more information in the IUPHAR Pharmacology Education Project: calcitonin

1. Albrandt K, Brady EM, Moore CX, Mull E, Sierzega ME, Beaumont K. (1995)
Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene.
Endocrinology, 136 (12): 5377-84. [PMID:7588285]
2. Armour SL, Foord S, Kenakin T, Chen WJ. (1999)
Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor.
J Pharmacol Toxicol Methods, 42 (4): 217-24. [PMID:11033437]
3. Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM. (2005)
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.
Mol. Pharmacol., 67 (5): 1655-65. [PMID:15692146]
4. Kuwasako K, Kitamura K, Nagoshi Y, Eto T. (2003)
Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins.
Biochem. Biophys. Res. Commun., 301 (2): 460-4. [PMID:12565884]
5. Leuthauser K, Gujer R, Aldecoa A, McKinney RA, Muff R, Fischer JA, Born W. (2000)
Receptor-activity-modifying protein 1 forms heterodimers with two G-protein-coupled receptors to define ligand recognition.
Biochem J., 351: 347-351. [PMID:11023820]
6. Muff R, B├╝hlmann N, Fischer JA, Born W. (1999)
An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3.
Endocrinology, 140 (6): 2924-7. [PMID:10342886]