Ligand id: 7148

Name: cilostazol

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 81.93
Molecular weight 369.22
XLogP 3.48
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to improve circulatory defecit in the legs which causes intermittent claudication.
Mechanism Of Action and Pharmacodynamic Effects
Cilostazol inhibits phosphodiesterase 3A. This results in increased cAMP levels in platelets and blood vessels and leads to inhibition of platelet aggregation and vasodilation, thereby improving circulation.
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