cilostazol   

GtoPdb Ligand ID: 7148

Synonyms: OPC-13013 | OPC-21 | Pletal®
cilostazol is an approved drug (FDA (1999))
Compound class: Synthetic organic
Comment: Cilostazol is a quinolinone-derivative phosphodiesterase (PDE) inhibitor.
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: cilostazol

2D Structure
Click here for structure editor
Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 81.93
Molecular weight 369.22
XLogP 3.48
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES O=C1CCc2c(N1)ccc(c2)OCCCCc1nnnn1C1CCCCC1
Isomeric SMILES O=C1CCc2c(N1)ccc(c2)OCCCCc1nnnn1C1CCCCC1
InChI InChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
InChI Key RRGUKTPIGVIEKM-UHFFFAOYSA-N
References
1. Maki T, Okamoto Y, Carare RO, Hase Y, Hattori Y, Hawkes CA, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda H et al.. (2014)
Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid.
Ann Clin Transl Neurol, 1 (8): 519-33. [PMID:25356424]
2. Sudo T, Tachibana K, Toga K, Tochizawa S, Inoue Y, Kimura Y, Hidaka H. (2000)
Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity.
Biochem. Pharmacol., 59 (4): 347-56. [PMID:10644042]