indapamide   Click here for help

GtoPdb Ligand ID: 7203

Synonyms: Hypen SR® | Lozol®
Approved drug
indapamide is an approved drug (FDA (1983))
Compound class: Synthetic organic
Comment: Indapamide is a thiazide diuretic drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 100.88
Molecular weight 365.06
XLogP 2.39
No. Lipinski's rules broken 0
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Canonical SMILES CC1Cc2c(N1NC(=O)c1ccc(c(c1)S(=O)(=O)N)Cl)cccc2
Isomeric SMILES CC1Cc2c(N1NC(=O)c1ccc(c(c1)S(=O)(=O)N)Cl)cccc2
InChI InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13(17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
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Summary of Clinical Use Click here for help
Used to treat oedema and hypertension.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
The drug's molecular mechanism of action is complex, and may include inhibition of the thiazide-sensitive sodium-chloride cotransporter, SLC12A3, antagonism of the voltage gated potassium channels, KCNQ1 and KCNE1, and increased synthesis of PGE2 (prostaglandin with vasodilatory action). See the DrugBank link for further details.
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