tropicamide   Click here for help

GtoPdb Ligand ID: 7319

Synonyms: Mydriacyl®
Approved drug
tropicamide is an approved drug (FDA (1960))
Compound class: Synthetic organic
Comment: Tropicamide is an antimuscarinic drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 53.43
Molecular weight 284.15
XLogP 1.34
No. Lipinski's rules broken 0
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Canonical SMILES CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1
Isomeric SMILES CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1
InChI InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
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Summary of Clinical Use Click here for help
Used as a short-acting mydriatic to allow better examination of the lens, vitreous humor, and retina.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Blocks the muscarinic acetylcholine M3 receptor (CHRM3) in the muscles of the eye which are responsible for controlling pupil size and lens shape. This causes pupil dilation.
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