tropicamide   Click here for help

GtoPdb Ligand ID: 7319

Synonyms: Mydriacyl®
Approved drug
tropicamide is an approved drug (FDA (1960))
Compound class: Synthetic organic
Comment: Tropicamide is an antimuscarinic drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 53.43
Molecular weight 284.15
XLogP 1.34
No. Lipinski's rules broken 0
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Canonical SMILES CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1
Isomeric SMILES CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1
InChI InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
M2 receptor Hs Antagonist Antagonist 7.2 pKi - 2
pKi 7.2 [2]
M3 receptor Primary target of this compound Hs Antagonist Antagonist 7.0 pKi - 2
pKi 7.0 [2]
M4 receptor Hs Antagonist Antagonist 6.9 pKi - 1
pKi 6.9 [1]
M5 receptor Hs Antagonist Antagonist 6.4 pKi - 2
pKi 6.4 [2]