Synonyms: Myalept® | r-metHuLeptin | R-methuleptin
metreleptin is an approved drug (FDA (2014), EMA (2018))
Compound class:
Peptide
Comment: Metreleptin is a recombinant, 147 amino acid (~16kDa), N-methionyl- analogue of human leptin [1]. Leptin is an adipokine (cytokine secreted by adipose tissue).
|
No information available. |
Summary of Clinical Use ![]() |
First approved by the US FDA in Feb 2014, to treat leptin deficiency and its associated symptoms in patients with congenital or acquired generalized lipodystrophy. |
Mechanism Of Action and Pharmacodynamic Effects ![]() |
Acts to regulate adipose-tissue mass via the leptin receptor (LEPR). |
External links ![]() |
For extended ADME data see the following: Drugs.com European Medicines Agency (EMA) |