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Synonyms: Myalept® | r-metHuLeptin | R-methuleptin
metreleptin is an approved drug (FDA (2014), EMA (2018))
Compound class:
Peptide or derivative
Comment: Metreleptin is a recombinant, 147 amino acid (~16kDa), N-methionyl- analogue of human leptin [1]. Leptin is an adipokine (cytokine secreted by adipose tissue).
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| No information available. |
Summary of Clinical Use  |
| First approved by the US FDA in Feb 2014, to treat leptin deficiency and its associated symptoms in patients with congenital or acquired generalized lipodystrophy. |
| Mechanism Of Action and Pharmacodynamic Effects |
| Acts to regulate adipose-tissue mass via the leptin receptor (LEPR). |
| External links |
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For extended ADME data see the following: Drugs.com European Medicines Agency (EMA) |
